Monday, 21 April 2014

Why Neanderthals never had brain disorders

Washington, April 21, 2014

 

In a significant discovery, scientists have found why modern humans develop brain disorders like autism or schizophrenia but our ancestor Neanderthals did not.

They have discovered the cellular equivalent of “on/off” switches that determine whether DNA is activated or not.

Hundreds of Neanderthals’ genes were turned “off” while the identical genes in today’s humans are turned “on”.

Alternatively, hundreds of other genes were turned “on” in Neanderthals but are “off” in people living today.

“The genes related to autism, as well as to schizophrenia and Alzheimer’s disease, were more likely to be “off” in Neanderthals than in modern humans,” said lead author Liram Carmel from Hebrew University of Jerusalem.

When dozens of brain-related genes became more active in today’s humans, it produced the harmful side effect of neurological illnesses, the study noted. The study was published in the journal Science . — IANS

Thursday, 3 April 2014

How does inhaled oxygen go out as carbon dioxide from our body while breathing?

PAVITHRA, Chennai

 

Inhaling, exhaling

While we breathe, we inhale oxygen along with nitrogen and carbon dioxide which co-exist in air. The inhaled air reaches lungs and enters alveoli where oxygen diffuses out from alveoli into blood, which enters into lungs via pulmonary capillaries, and carbon dioxide diffuses into alveoli from blood. This simple diffusion happens because of partial pressure difference between oxygen and carbon dioxide in blood and alveoli.

In alveoli, partial pressure of oxygen is relatively higher than carbon dioxide whereas, in the blood which enters in to the lungs, partial pressure of carbon dioxide is higher than oxygen.

Carbon dioxide entered into the alveoli by diffusion will be exhaled by lungs while we breathe. Blood leaving the pulmonary capillaries is rich in oxygen and it goes to the left atrium and pumped by heart into the systemic circulation of our body.

For our body cells to perform various functions, they need energy, and this energy is generated by producing ATP molecules via burning fuel molecules such as carbohydrates using oxygen.

The side product of this reaction is carbon dioxide. So in the body cells, partial pressure of carbon dioxide is higher than oxygen.

Hence, when oxygen rich blood reaches body cells by systemic circulation, because of partial pressure gradient, oxygen will diffuse into the body cells and carbon dioxide will diffuse into blood.

Now the carbon dioxide rich blood will return to the heart (right atrium) and then pumped into lungs. In the lungs, carbon dioxide will be exhaled as explained in the beginning. This process is a cycle and oxygen is taken up and carbon dioxide is released out continuously in our body.

Dr. K. K. CHERALATHAN

Associate Professor

Materials Chemistry Division

School of Advanced Sciences

VIT University, Vellore

Copyright© 2014, The Hindu

During night hours, leaves of some kinds of plants/trees are seen closed. Why?

P. HABEEB RAHMAN

Madurai, Tamil Nadu

Leaves of some plants, trees and petals of flowers close at night with the onset of darkness. This is called Nyctinasty. Nyctinasty is a non-directional response of plants, animals due to changes in temperature or light in the surrounding environment.

It is a circadian (diurnal) rhythmic movement of certain plants, mainly members of Fabaceae (bean family) and certain Cucurbits (gourd family). Also, leaves of plants belonging to the bean family ( leguminosae ) exhibit this nyctinasty. The word nyctinasty has been derived from two Greek words, nux/nukt means night+ nasti meaning pressed.

These movements are associated with the diurnal variation of light and temperature and are controlled by the circadian clock and light receptor chemicals such as cytochromes present in the plants. Several leaf opening and closing factors are in turn controlled by the plant biochemical pathways. In plants belonging to leguminosae , the leaf is not a simple leaf but a compound leaf wherein small leaflets are arranged on the branched or non-branched rachis (leaf stalk). The leaf base is called a pulvinus leaf base as it is swollen.

The compound leaf is attached to the stem by means of this swollen leaf base. Anatomically this pulvinate leaf base is responsible for controlling the opening and closure of the entire leaf depending on the temperature and light conditions of the surrounding environment.

As darkness sets in the turgor pressure of the leaf base changes which will be transmitted till the tip of the leaf along the entire rachis. Hence the entire leaf folds up resulting in the closure of the leaf. Here changes of potassium flux along the dorsal and ventral cells of the pulvinus due to the far red aerobic phytochromal responses bring about the changes of turgor pressure in the cells of the pulvinus. Hence the entire leaf along with the leaf base contracts during nights or under high temperature conditions. In the daylight the reverse phenomenon occurs and the leaf opens up.

Dr. T. BHAVANI

Bangalore

Copyright© 2014, The Hindu

Honey, I shrunk the mass spectrometer

March 27, 2014

R. PRASAD

 

IIT Madras team was able to create ions from any sample even at one volt

Innovative:Rahul Narayanan of the Department of Chemistry, IIT Madras and the lead author of the paper performs an experiment using nanotube-coated paper.— photo: Special Arrangement

Innovative:Rahul Narayanan of the Department of Chemistry, IIT Madras and the lead author of the paper performs an experiment using nanotube-coated paper.— photo: Special Arrangement

Mass spectrometers that are as small as a smart phone and require as little as one volt — a 3,000-time reduction in potential — to create an electric field which would turn a sample into ions for identification of composition may soon become a reality.

The feat of shrinking the ion source that requires very little voltage was achieved by a team led by Prof. T. Pradeep of the Department of Chemistry, IIT Madras. The results were published last week in the Angewandte Chemie International journal.

Conventionally, a solution of the sample is electrosprayed at 3,000 volts to create charged droplets that become ions. The ions are, in turn, analysed to find the composition or chemical constituents in the case of a sample mixture.

The massive reduction in voltage requirement became possible by using carbon nanotube-impregnated paper to act as a substrate on which the sample was deposited. If the conventional method uses very high voltage to create a strong electric field, the sharp protrusions of the carbon nanotubes help in creating the high electric field by using very low voltage.

“One volt over a few nanometres creates an electric field equivalent to 10 million volts over a centimetre,” Prof. Pradeep explained. “The whole idea was to keep the nanotubes separated from each other. Normally they get bundled.”

Once nanotubes get bundled, they turn out to become large wire-like structures thereby increasing the voltage required to create an electric field. “Earlier experiments [by others] using carbon nanotubes failed as the nanotubes were bundled,” he said. In fact, standard procedures are available to disperse the nanotubes.

Incidentally, the order in which Prof. Pradeep’s experiment progressed was unusual. “I had been after this method for a long time. I knew ionisation is possible and can be detected using low voltage. But the answer came first,” he recalled. “I understood that by using the nanotube dispersion technique I could get ions. So the ions came first, and I looked at why this happened.” And he soon figured it out. “I realised that ions were observed as the nanotubes were separated,” he said.

“All good science is commonsense,” he noted. “When you look back, [the way] many science breakthroughs [happen] look simple… quite silly. But if you had told this [miniaturizing mass spectrometer] 20 years ago, people would not have believed you.”

A few puzzles remain to be solved. The researchers are yet to decipher where the samples get charged — along the entire length of the nanotube or just at the tip. It is also not clear why molecules present in the air don’t get ionised and create their own signals (technically called as noise).

Earlier, scientists succeeded in shrinking the size of the analyser and detectors to 1 cm{+3}each. Now, by shrinking the size of the ion source, the possibility of simplifying mass spectrometry for analysing various substances opens up.

“If you have a good vacuum system and controlled electronics, we can shrink a mass spectrometer to smart-phone size… we can simplify it. That’s the importance of this discovery,” he emphasised.

He foresees a day not too far away when gently rubbing the nanotube-coated paper on any object — an apple or a tablet — will be sufficient to collect samples for analysis in a lab. The nanotube-coated substrate can also be reused. In all, there is a real possibility of completely rewriting the way sample testing gets done.

“So what it means [is that] you can collect samples remotely and analyse them elsewhere for disease or pollution prevention or any such thing,” he noted. “In a sense, we can make a mass spectrometer reach a wider audience.” The mass spectrometer is a sophisticated instrument and has been out of bounds to the common man.

Producing a nanotube-coated substrate is also quite simple. Nanotubes can be grown separately and then coated on the substrate and, behold, it is ready for sample loading.

Since samples can be collected by gently rubbing the substrate on the material, there is a possibility of some tubes breaking and sticking to the surface of the material tested. Will such broken nanotubes cause any health hazard?

“We must ensure that the substrate is holding the nanotubes firmly, so no nanotubes stick to the sample tested,” he noted.

Copyright© 2014, The Hindu

Was dark matter observed in Kolar Gold Field experiments?

March 27, 2014

R. Ramachandran

 

The unusual events, which were detected in a long, 2.3 km deep tunnel, occurred during both the phases — 1960s-70s, and 1980s

Important finding:The proton decay detector used in the second phase proton decay experiments at KGF. — photo: special arrangement

Important finding:The proton decay detector used in the second phase proton decay experiments at KGF. — photo: special arrangement

The handful of unusual events observed in the underground experiments at the Kolar Gold Field (KGF) mines during the 1960-70s and the 1980s, which have remained unexplained to this day, may have been due to the decays of hitherto unseen Dark Matter (DM) particles.

This interesting hypothesis has been put forward by Profs. G. Rajasekaran and M. V. N. Murthy of the Institute of Mathematical Sciences (IMSc), Chennai, in a paper published in the latest issue of the physics journal Pramana.

While at that time the events were interpreted to be perhaps due to the decay of a massive unknown particle, subsequent accelerator experiments at CERN in Europe and Fermilab in the U.S. did not find evidence for any such massive particle. Also, the currently highly successful Standard Model of elementary particles, bolstered by the discovery of the Higgs particle in 2012, cannot accommodate such a massive particle.

The postulate of DM was put forward to account for the extreme velocities with which galaxies and clusters of galaxies are observed to be rotating that the gravity generated by their observable matter alone cannot explain. At such speeds they should have been torn apart long ago. It is believed that something that cannot be seen directly with light (electromagnetic radiation, in general) — and hence the name — is providing that extra mass, generating the extra gravity, needed to hold them together.

DM dominates the matter in the universe, outweighing all the visible matter by nearly six times, but its existence can be inferred only from the gravitational effect it seems to have on visible matter. Though existence of DM is now accepted, and it is all around us with varying densities, its nature has remained a mystery and various candidate DM particles have been proposed.

However, DM as a possible source of the ‘Kolar events’ was never considered until now perhaps because the concept of DM was yet to become of mainstream physics discussions at that time. The recent claim by the DM search experiment called CDMSII of possible evidence of a DM particle with a mass of 5-10 GeV (in energy units) has provided the motivation for the IMSc scientists to revisit the ‘Kolar events’ from a DM perspective.

The KGF experiments, which were sponsored by the Tata Institute of Fundamental Research (TIFR), were carried out in two phases. The first phase experiments, during the 1960s-70s, studied cosmic ray neutrino interactions and the second, during the 1980s, studied proton decay and set limits on proton’s lifetime. The unusual events, which were detected in a long tunnel at a depth of 2.3 km, were seen during both the phases.

While, in principle, such events could be produced by cosmic ray neutrinos (or antineutrinos) interacting with air molecules in the gap between the rock wall and the detectors, the large number seen could not be explained by known processes. Standard processes due to neutrinos or muons would only produce such events with a probability of less than one in 100 years. Here one was seeing eight such events (5 in the first phase and 3 in the second) in about as many years.

Instead of the early interpretation of cosmic ray neutrinos interacting with the surrounding rock and producing a massive particle which subsequently decayed to give rise to these anomalous events, the authors interpret the events to have been caused by the decay of a neutral DM particle with a mass of about 5-10 GeV and with a lifetime of the order of the lifetime of the universe (about 1010 years or 10 billion years).

The CDMSII experiment recently observed three events, which have been interpreted to be due to a DM particle with a mass of 8.2 GeV. This falls within the range that the IMSc scientists require for their interpretation. It may, however, be pointed out that the jury on this claim is still out as another DM search experiment LUX has not seen any evidence so far.

Arguing that not much attention has been paid to decaying DM particles, they choose a model that has both stable and unstable DM particles.

This gives them a DM particle lifetime of 1010 years as against the generally accepted value of greater than 1011 years. Using an appropriate detection volume of 1010 cm3 (from the known dimensions of the tunnel) and a DM density of 1 particle/cm3, they get a value for the rate of events that matches with the rate observed at Kolar.

“It is miraculous that such a crude estimate gives remarkable agreement. So there could be some truth in our speculation,” points out Rajasekaran. They, however, recognise that, if the lifetime is greater, or if the density is an order of magnitude smaller, DM could not have caused any Kolar event, as some critics of this work have also noted.

“Quibbling about these values does not make much sense when we know nothing about the nature of DM. All estimates are, after all, guesstimates. All we are saying is that, if our speculation is correct, it solves two problems in one stroke: explaining the anomalous Kolar events and observation of DM,” he adds.

“Independent of the Kolar events and their interpretation, any large underground detector must be in a position to see the decays of an unstable DM particle,” says the paper.

Neutrino experiments such as OPERA and MINOS, where the detector is similar to KGF, are well suited to look for such decays, they note. But, more importantly, the paper highlights the importance of considering DM decays in the analyses of experimental data. “Non-observation of decays may be used to set limits on [DM particle] lifetime,” the paper observes.

Copyright© 2014, The Hindu

China starts building its second neutrino experiment

March 27, 2014

VASUDEVAN MUKUNTH

China has started constructing a $330-million underground neutrino detector this week which, upon completion, will have similar goals as the Indian Neutrino Observatory (INO) coming up in Theni, Tamil Nadu. Situated at a site 150 km west of Hong Kong, the Jiangmen Underground Neutrino Observatory (JUNO) is being built underground by the Institute of High Energy Physics (IHEP), Beijing.

It will supplement the Daya Bay Reactor Neutrino Experiment, a China-based multinational neutrino physics centre located 52 km northeast of Hong Kong that has been operating since 2011. In fact, as Daya Bay studies neutrinos coming through space toward Earth, JUNO will study those from two nuclear reactors being constructed at locations some 50 km away.

If all goes well, the lab will open in 2020 and operate well beyond 2040. “It will be a big challenge to build such a large underground lab and a detector in five years,” Ifang Wang, Director, IHEP, told physicsworld . Neutrinos are colloquially called “ghost particles” because they travel at almost the speed of light, hardly interact with matter, and are very light. Therefore, trapping and measuring a neutrino requires extremely sensitive equipment shielded from interfering radiation.

The JUNO detector will be situated in a dome of diameter 50 m and height 80 m, about 700 m underground. Its detector comprises 20,000 tonnes of a liquid scintillator surrounded by more than 15,000 photomultiplier tubes. The liquid will produce a scintillation, or flash of light, when a neutrino strikes a hydrogen atom. The flash will be picked up by the tubes as an electric signal.

There are three kinds, or flavours, of neutrinos, designated 1, 2 and 3. Each flavour is known to spontaneously transform into the other, a process called oscillation that is characteristic of particles that have mass. However, physicists have been unable to measure their masses. What they have been able to accomplish is find their difference. Of late, interest has grown in the mass of neutrino-3 with respected to the other two, which is what INO and JUNO will study. Together, these detectors will join the already operating Hyper-Kamiokande in Japan and the NOvA in the U.S.

Copyright© 2014, The Hindu

Missing hormone in birds found in 3 species

March 27, 2014

AP

Leptin, the hormone that regulates body fat storage, metabolism and appetite would enable physiological feats of some birds. However, elusive until now, it is found in the peregrine falcon, mallard duck and zebra finch.