Monday, 21 April 2014

Why Neanderthals never had brain disorders

Washington, April 21, 2014

 

In a significant discovery, scientists have found why modern humans develop brain disorders like autism or schizophrenia but our ancestor Neanderthals did not.

They have discovered the cellular equivalent of “on/off” switches that determine whether DNA is activated or not.

Hundreds of Neanderthals’ genes were turned “off” while the identical genes in today’s humans are turned “on”.

Alternatively, hundreds of other genes were turned “on” in Neanderthals but are “off” in people living today.

“The genes related to autism, as well as to schizophrenia and Alzheimer’s disease, were more likely to be “off” in Neanderthals than in modern humans,” said lead author Liram Carmel from Hebrew University of Jerusalem.

When dozens of brain-related genes became more active in today’s humans, it produced the harmful side effect of neurological illnesses, the study noted. The study was published in the journal Science . — IANS

Thursday, 3 April 2014

How does inhaled oxygen go out as carbon dioxide from our body while breathing?

PAVITHRA, Chennai

 

Inhaling, exhaling

While we breathe, we inhale oxygen along with nitrogen and carbon dioxide which co-exist in air. The inhaled air reaches lungs and enters alveoli where oxygen diffuses out from alveoli into blood, which enters into lungs via pulmonary capillaries, and carbon dioxide diffuses into alveoli from blood. This simple diffusion happens because of partial pressure difference between oxygen and carbon dioxide in blood and alveoli.

In alveoli, partial pressure of oxygen is relatively higher than carbon dioxide whereas, in the blood which enters in to the lungs, partial pressure of carbon dioxide is higher than oxygen.

Carbon dioxide entered into the alveoli by diffusion will be exhaled by lungs while we breathe. Blood leaving the pulmonary capillaries is rich in oxygen and it goes to the left atrium and pumped by heart into the systemic circulation of our body.

For our body cells to perform various functions, they need energy, and this energy is generated by producing ATP molecules via burning fuel molecules such as carbohydrates using oxygen.

The side product of this reaction is carbon dioxide. So in the body cells, partial pressure of carbon dioxide is higher than oxygen.

Hence, when oxygen rich blood reaches body cells by systemic circulation, because of partial pressure gradient, oxygen will diffuse into the body cells and carbon dioxide will diffuse into blood.

Now the carbon dioxide rich blood will return to the heart (right atrium) and then pumped into lungs. In the lungs, carbon dioxide will be exhaled as explained in the beginning. This process is a cycle and oxygen is taken up and carbon dioxide is released out continuously in our body.

Dr. K. K. CHERALATHAN

Associate Professor

Materials Chemistry Division

School of Advanced Sciences

VIT University, Vellore

Copyright© 2014, The Hindu

During night hours, leaves of some kinds of plants/trees are seen closed. Why?

P. HABEEB RAHMAN

Madurai, Tamil Nadu

Leaves of some plants, trees and petals of flowers close at night with the onset of darkness. This is called Nyctinasty. Nyctinasty is a non-directional response of plants, animals due to changes in temperature or light in the surrounding environment.

It is a circadian (diurnal) rhythmic movement of certain plants, mainly members of Fabaceae (bean family) and certain Cucurbits (gourd family). Also, leaves of plants belonging to the bean family ( leguminosae ) exhibit this nyctinasty. The word nyctinasty has been derived from two Greek words, nux/nukt means night+ nasti meaning pressed.

These movements are associated with the diurnal variation of light and temperature and are controlled by the circadian clock and light receptor chemicals such as cytochromes present in the plants. Several leaf opening and closing factors are in turn controlled by the plant biochemical pathways. In plants belonging to leguminosae , the leaf is not a simple leaf but a compound leaf wherein small leaflets are arranged on the branched or non-branched rachis (leaf stalk). The leaf base is called a pulvinus leaf base as it is swollen.

The compound leaf is attached to the stem by means of this swollen leaf base. Anatomically this pulvinate leaf base is responsible for controlling the opening and closure of the entire leaf depending on the temperature and light conditions of the surrounding environment.

As darkness sets in the turgor pressure of the leaf base changes which will be transmitted till the tip of the leaf along the entire rachis. Hence the entire leaf folds up resulting in the closure of the leaf. Here changes of potassium flux along the dorsal and ventral cells of the pulvinus due to the far red aerobic phytochromal responses bring about the changes of turgor pressure in the cells of the pulvinus. Hence the entire leaf along with the leaf base contracts during nights or under high temperature conditions. In the daylight the reverse phenomenon occurs and the leaf opens up.

Dr. T. BHAVANI

Bangalore

Copyright© 2014, The Hindu

Honey, I shrunk the mass spectrometer

March 27, 2014

R. PRASAD

 

IIT Madras team was able to create ions from any sample even at one volt

Innovative:Rahul Narayanan of the Department of Chemistry, IIT Madras and the lead author of the paper performs an experiment using nanotube-coated paper.— photo: Special Arrangement

Innovative:Rahul Narayanan of the Department of Chemistry, IIT Madras and the lead author of the paper performs an experiment using nanotube-coated paper.— photo: Special Arrangement

Mass spectrometers that are as small as a smart phone and require as little as one volt — a 3,000-time reduction in potential — to create an electric field which would turn a sample into ions for identification of composition may soon become a reality.

The feat of shrinking the ion source that requires very little voltage was achieved by a team led by Prof. T. Pradeep of the Department of Chemistry, IIT Madras. The results were published last week in the Angewandte Chemie International journal.

Conventionally, a solution of the sample is electrosprayed at 3,000 volts to create charged droplets that become ions. The ions are, in turn, analysed to find the composition or chemical constituents in the case of a sample mixture.

The massive reduction in voltage requirement became possible by using carbon nanotube-impregnated paper to act as a substrate on which the sample was deposited. If the conventional method uses very high voltage to create a strong electric field, the sharp protrusions of the carbon nanotubes help in creating the high electric field by using very low voltage.

“One volt over a few nanometres creates an electric field equivalent to 10 million volts over a centimetre,” Prof. Pradeep explained. “The whole idea was to keep the nanotubes separated from each other. Normally they get bundled.”

Once nanotubes get bundled, they turn out to become large wire-like structures thereby increasing the voltage required to create an electric field. “Earlier experiments [by others] using carbon nanotubes failed as the nanotubes were bundled,” he said. In fact, standard procedures are available to disperse the nanotubes.

Incidentally, the order in which Prof. Pradeep’s experiment progressed was unusual. “I had been after this method for a long time. I knew ionisation is possible and can be detected using low voltage. But the answer came first,” he recalled. “I understood that by using the nanotube dispersion technique I could get ions. So the ions came first, and I looked at why this happened.” And he soon figured it out. “I realised that ions were observed as the nanotubes were separated,” he said.

“All good science is commonsense,” he noted. “When you look back, [the way] many science breakthroughs [happen] look simple… quite silly. But if you had told this [miniaturizing mass spectrometer] 20 years ago, people would not have believed you.”

A few puzzles remain to be solved. The researchers are yet to decipher where the samples get charged — along the entire length of the nanotube or just at the tip. It is also not clear why molecules present in the air don’t get ionised and create their own signals (technically called as noise).

Earlier, scientists succeeded in shrinking the size of the analyser and detectors to 1 cm{+3}each. Now, by shrinking the size of the ion source, the possibility of simplifying mass spectrometry for analysing various substances opens up.

“If you have a good vacuum system and controlled electronics, we can shrink a mass spectrometer to smart-phone size… we can simplify it. That’s the importance of this discovery,” he emphasised.

He foresees a day not too far away when gently rubbing the nanotube-coated paper on any object — an apple or a tablet — will be sufficient to collect samples for analysis in a lab. The nanotube-coated substrate can also be reused. In all, there is a real possibility of completely rewriting the way sample testing gets done.

“So what it means [is that] you can collect samples remotely and analyse them elsewhere for disease or pollution prevention or any such thing,” he noted. “In a sense, we can make a mass spectrometer reach a wider audience.” The mass spectrometer is a sophisticated instrument and has been out of bounds to the common man.

Producing a nanotube-coated substrate is also quite simple. Nanotubes can be grown separately and then coated on the substrate and, behold, it is ready for sample loading.

Since samples can be collected by gently rubbing the substrate on the material, there is a possibility of some tubes breaking and sticking to the surface of the material tested. Will such broken nanotubes cause any health hazard?

“We must ensure that the substrate is holding the nanotubes firmly, so no nanotubes stick to the sample tested,” he noted.

Copyright© 2014, The Hindu

Was dark matter observed in Kolar Gold Field experiments?

March 27, 2014

R. Ramachandran

 

The unusual events, which were detected in a long, 2.3 km deep tunnel, occurred during both the phases — 1960s-70s, and 1980s

Important finding:The proton decay detector used in the second phase proton decay experiments at KGF. — photo: special arrangement

Important finding:The proton decay detector used in the second phase proton decay experiments at KGF. — photo: special arrangement

The handful of unusual events observed in the underground experiments at the Kolar Gold Field (KGF) mines during the 1960-70s and the 1980s, which have remained unexplained to this day, may have been due to the decays of hitherto unseen Dark Matter (DM) particles.

This interesting hypothesis has been put forward by Profs. G. Rajasekaran and M. V. N. Murthy of the Institute of Mathematical Sciences (IMSc), Chennai, in a paper published in the latest issue of the physics journal Pramana.

While at that time the events were interpreted to be perhaps due to the decay of a massive unknown particle, subsequent accelerator experiments at CERN in Europe and Fermilab in the U.S. did not find evidence for any such massive particle. Also, the currently highly successful Standard Model of elementary particles, bolstered by the discovery of the Higgs particle in 2012, cannot accommodate such a massive particle.

The postulate of DM was put forward to account for the extreme velocities with which galaxies and clusters of galaxies are observed to be rotating that the gravity generated by their observable matter alone cannot explain. At such speeds they should have been torn apart long ago. It is believed that something that cannot be seen directly with light (electromagnetic radiation, in general) — and hence the name — is providing that extra mass, generating the extra gravity, needed to hold them together.

DM dominates the matter in the universe, outweighing all the visible matter by nearly six times, but its existence can be inferred only from the gravitational effect it seems to have on visible matter. Though existence of DM is now accepted, and it is all around us with varying densities, its nature has remained a mystery and various candidate DM particles have been proposed.

However, DM as a possible source of the ‘Kolar events’ was never considered until now perhaps because the concept of DM was yet to become of mainstream physics discussions at that time. The recent claim by the DM search experiment called CDMSII of possible evidence of a DM particle with a mass of 5-10 GeV (in energy units) has provided the motivation for the IMSc scientists to revisit the ‘Kolar events’ from a DM perspective.

The KGF experiments, which were sponsored by the Tata Institute of Fundamental Research (TIFR), were carried out in two phases. The first phase experiments, during the 1960s-70s, studied cosmic ray neutrino interactions and the second, during the 1980s, studied proton decay and set limits on proton’s lifetime. The unusual events, which were detected in a long tunnel at a depth of 2.3 km, were seen during both the phases.

While, in principle, such events could be produced by cosmic ray neutrinos (or antineutrinos) interacting with air molecules in the gap between the rock wall and the detectors, the large number seen could not be explained by known processes. Standard processes due to neutrinos or muons would only produce such events with a probability of less than one in 100 years. Here one was seeing eight such events (5 in the first phase and 3 in the second) in about as many years.

Instead of the early interpretation of cosmic ray neutrinos interacting with the surrounding rock and producing a massive particle which subsequently decayed to give rise to these anomalous events, the authors interpret the events to have been caused by the decay of a neutral DM particle with a mass of about 5-10 GeV and with a lifetime of the order of the lifetime of the universe (about 1010 years or 10 billion years).

The CDMSII experiment recently observed three events, which have been interpreted to be due to a DM particle with a mass of 8.2 GeV. This falls within the range that the IMSc scientists require for their interpretation. It may, however, be pointed out that the jury on this claim is still out as another DM search experiment LUX has not seen any evidence so far.

Arguing that not much attention has been paid to decaying DM particles, they choose a model that has both stable and unstable DM particles.

This gives them a DM particle lifetime of 1010 years as against the generally accepted value of greater than 1011 years. Using an appropriate detection volume of 1010 cm3 (from the known dimensions of the tunnel) and a DM density of 1 particle/cm3, they get a value for the rate of events that matches with the rate observed at Kolar.

“It is miraculous that such a crude estimate gives remarkable agreement. So there could be some truth in our speculation,” points out Rajasekaran. They, however, recognise that, if the lifetime is greater, or if the density is an order of magnitude smaller, DM could not have caused any Kolar event, as some critics of this work have also noted.

“Quibbling about these values does not make much sense when we know nothing about the nature of DM. All estimates are, after all, guesstimates. All we are saying is that, if our speculation is correct, it solves two problems in one stroke: explaining the anomalous Kolar events and observation of DM,” he adds.

“Independent of the Kolar events and their interpretation, any large underground detector must be in a position to see the decays of an unstable DM particle,” says the paper.

Neutrino experiments such as OPERA and MINOS, where the detector is similar to KGF, are well suited to look for such decays, they note. But, more importantly, the paper highlights the importance of considering DM decays in the analyses of experimental data. “Non-observation of decays may be used to set limits on [DM particle] lifetime,” the paper observes.

Copyright© 2014, The Hindu

China starts building its second neutrino experiment

March 27, 2014

VASUDEVAN MUKUNTH

China has started constructing a $330-million underground neutrino detector this week which, upon completion, will have similar goals as the Indian Neutrino Observatory (INO) coming up in Theni, Tamil Nadu. Situated at a site 150 km west of Hong Kong, the Jiangmen Underground Neutrino Observatory (JUNO) is being built underground by the Institute of High Energy Physics (IHEP), Beijing.

It will supplement the Daya Bay Reactor Neutrino Experiment, a China-based multinational neutrino physics centre located 52 km northeast of Hong Kong that has been operating since 2011. In fact, as Daya Bay studies neutrinos coming through space toward Earth, JUNO will study those from two nuclear reactors being constructed at locations some 50 km away.

If all goes well, the lab will open in 2020 and operate well beyond 2040. “It will be a big challenge to build such a large underground lab and a detector in five years,” Ifang Wang, Director, IHEP, told physicsworld . Neutrinos are colloquially called “ghost particles” because they travel at almost the speed of light, hardly interact with matter, and are very light. Therefore, trapping and measuring a neutrino requires extremely sensitive equipment shielded from interfering radiation.

The JUNO detector will be situated in a dome of diameter 50 m and height 80 m, about 700 m underground. Its detector comprises 20,000 tonnes of a liquid scintillator surrounded by more than 15,000 photomultiplier tubes. The liquid will produce a scintillation, or flash of light, when a neutrino strikes a hydrogen atom. The flash will be picked up by the tubes as an electric signal.

There are three kinds, or flavours, of neutrinos, designated 1, 2 and 3. Each flavour is known to spontaneously transform into the other, a process called oscillation that is characteristic of particles that have mass. However, physicists have been unable to measure their masses. What they have been able to accomplish is find their difference. Of late, interest has grown in the mass of neutrino-3 with respected to the other two, which is what INO and JUNO will study. Together, these detectors will join the already operating Hyper-Kamiokande in Japan and the NOvA in the U.S.

Copyright© 2014, The Hindu

Missing hormone in birds found in 3 species

March 27, 2014

AP

Leptin, the hormone that regulates body fat storage, metabolism and appetite would enable physiological feats of some birds. However, elusive until now, it is found in the peregrine falcon, mallard duck and zebra finch.

'The opposition to GM crops is not based on science... There is no substantiated case of a health impact, even so much as a headache'

 

Shekhar Gupta : Tue Nov 26 2013, 16:35 hrs

 

Walk the talkMark Lynas

 

An early member of anti-GM movement, Mark Lynas made a turnaround early this year. Speaking to The Indian Express Editor-in-Chief Shekhar Gupta, on NDTV 24X7, Lynas says science won him over, explains how GM myths take root, and flays activists for denying farmers the right to make choices

You used to sneak into people's farms and burn crops because they used genetically modified technology. And then suddenly, sometime early this year, you made a complete turnaround. An environmental activist in some ways, the founder of the anti-GM movement...

Not the founder, I was one of the early members. But this was a very broad, diverse coalition which involved Prince Charles, the right-wing press, the middle-class people. I look back and I think, 'What went wrong?'. How come we all came to believe something which was not just incorrect but the precise opposite of the truth the scientists were telling us? It took me 10 years to really understand that the science wasn't supporting what we as activists were saying. And that was a very long process, a difficult process. I think it has cost me, if not credibility, a lot of grey hair.

You are a brave man.

I am (taking on ideology) in some ways because the environmental movement has an ideological opposition to genetically modified crops. It is not based on science, it is not based on any rational assessment of risks and benefits. It is something about the fear of new technology, the fear of the 'new'. And when these fears become widely believed, people believe all sorts of myths about GM being poisonous, about causing sterility. And the scientists cannot understand why these myths have become so pervasive. They are now worldwide.

Describe this ideology and compare this with religious ideology, as you see it.

There is big suspicion that there is something about GM technology that is going to bring multinationals to enslave farmers. The other is that there is something inherently dangerous about GM. Because it is a powerful technology. We can see scientists moving genes from plants into animals because, of course, all living things share the same genetic system of DNA.

But this ideology is not limited to GM. Like all religious ideologies have multiple demons, so does this.

Yes, the ideology is to some extent anti-progressive and anti-development. The insistence is that farmers, in developing countries in particular, should not have access to new technology, to new crops which are more productive. There is also an opposition to hybrid crops, to mechanisation.

The pesticides...

The pesticides, true. One of the things I like about GM is that it enables us to reduce the use of pesticides.

Is there sufficient evidence that GM reduces the use of pesticides? Bt cotton...

The whole point of Bt cotton is that it has a genetic structure which enables it to target the pest itself. So, when the pest goes into the cotton plant, only the pest dies. If you are spraying it, you can imagine, all the insects die. That affects the birds, it affects biodiversity more widely.

What was the scientific evidence on which you based your opposition to GM food?

I did not base my opposition on scientific evidence, that is the point. And so it was when I started writing scientific books that I realised there was a conflict between my pro-science position on climate change and my anti-science position on biotechnology. I then had to change my mind to become pro-science across the whole board. Because I was getting my information from activist groups, like most people do, like the media does. Activist groups were telling me that there was something evil...

On these issues, let me tell you, media around the world does not want to be confused with facts... So were you misled? Were you lazy?

I think I was ignorant, misinformed, I will put it that way. I never knowingly made a statement I knew was incorrect. I wouldn't say I am a liar because I didn't say something I knew to be untrue. What I was doing was repeating the myths which had already been stated numerous times by Greenpeace and other organisations. Because I was an environmentalist. How many environmentalists can you get to walk down this path and tell you a scientific perspective on GMOs (genetically modified organisms)? Almost none. This is a major failing of the environmental movement which has done so much

good in terms of deforestation, over-fishing, biodiversity...

And climate change... Where you are still pro-science.

I am like that (clasping hands) with Greenpeace on climate change. That is why I cannot understand why they have a pro-science position on climate change and an anti-science position on biotechnology, where a vast majority of scientists would say they are talking rubbish.

When you made this turnaround, one of our most prominent and respected activists, Vandana Shiva, said you speaking thus was like giving rapists the freedom to rape.

I cannot see why you describe Vandana Shiva as either prominent or respected. I mean she does knowingly make statements which are clearly inaccurate and incorrect about farmer suicides and other assertions about Monsanto, BT cotton... I mean not just wrong, I would say those were lies... To compare GMOs with that (rape) was obscene, offensive and a betrayal of humanitarian and moral values.

But Shiva is well meaning. Why is she doing it? She is not an enemy of India or Indian farmers.

I think she is. Her insistence on only the traditional on how farmers should live denies the ability of children in rural areas to ever improve themselves, to be rocket scientists, or whatever. How is it that somebody who never gets proper education because they only have traditional cultures and values — they can never even leave the village — get to change the world?

...I am no expert but some of the Indian farmers I have spoken to have said we want the choice to grow new technologies. She and the activists are just trying to ban all of these new crops. That is a denial of choice. I would not even say I am pro-GM; I am pro-choice. Farmers should have the choice to benefit from modern science, just like everyone else.

Some people say you took a lot of money from 'evil' MNCs.

That is not true.

Why should I trust you now, if you now say that everything you told me all these years was nonsense?

Would you trust somebody who can change his mind according to changing evidence, or would you trust somebody who holds on to the same position no matter what the evidence says?

John Maynard Keynes said this: 'When facts change, I change my mind. What do you do sir?'.

That is the problem we have. The people who project themselves as leaders have to create an image of infallibility, and so they can never admit to doing wrong. They can never admit to doing a U-turn. But actually, a U-turn makes sense if you assess the science and you find your policy is wrong.

You talked about the ideology and science of climate change and GM, and you said the opposition to GM is a mix of Leftist and anti-corporate ideologies. Where does the campaign on climate change come in? A lot of that is also anti-corporate and that is also Left.

The environmental movement so quickly accepted the science on climate change because it appeared to conform to pre-existing ideological positions, which were anti-big business, anti-fossil fuel companies, and actually the fossil fuel companies are causing the climate change. But on biotechnology, the anti-corporate agenda didn't fit the science because the science says genetic modification is safe, and can be used to benefit the environment.

And then you have a funny situation where the ideologies of the Left oppose GM food but the ideologies of the Right deny climate change.

Unfortunately in these things there are clear political boundaries... It is the ideology which defines the scientific perspective.

Are you trying to persuade anybody in India?

I am here with the Borlaug Global Rust Initiative, which is a meeting of scientists from across the world looking at a problem of wheat rust, which is potentially a huge threat... UT-99 can affect all the varieties which have been yielding such good returns for the last several decades. Scientists have identified the genes which can protect and can give rust resistance. But unless you can use GM technology to get them into wheat, we cannot use this.

Are you meeting anyone in the government?

The Agriculture Minister. I am not meeting Jairam Ramesh, whom I have crossed swords with. I thought his moratorium on BT brinjal was a betrayal of scientific values and a failure of personal leadership.

Why do you say so?

Because he was given a choice between superstitions on one side and scientific evidence on the other. He chose superstitions because it was the populist thing to do. And, obviously, he is the kind of politician who only thinks about the next election. But politics is about leadership. You have to assess the evidence, you have to form a judgment about what is right and then lead people on that basis. Ramesh was just behind everybody, trying to take a safe space.

I will put in one disclaimer on his behalf: he has never fought an election and is unlikely to fight one. But he did quote a bunch of experts or scientists.

These are scientists who would have been brought to the fore by activists. I could name at least five scientists who do not believe in climate change. Would that mean there is a 50:50 debate on this issue? No, it means that 97, 98 per cent of scientists say that climate change is real and only a tiny percentage says it is not. It is the same with biotechnology. You can find one or two scientists but most of them have activist backgrounds and do not actually have the credentials of being scientifically active.

When you made your turnaround, Ramesh told The Indian Express that he did not take you seriously in any case.

Which is fine. But I do not think he takes science seriously, which is much worse... He has a mandate as an environment minister to do what is best for environment. It is clear that GM crops can actually reduce pesticide use... Had BT brinjal been commercialised, there would have been less pesticide residue in the brinjal product.

Do you believe it would make all the native varieties of brinjal extinct?

I can't see why that is even logical. Why should that happen? What is going to make them go extinct?

Maybe because BT brinjal will be so profitable, they will stop growing any other variety.

So Ramesh is saying you cannot use a technology that works because those that do not will disappear. How useful is that?

Why are you so sceptical of organic agriculture?

Because I think biotechnology is the only system that can make organic agriculture work. We can have crops that protect themselves through their own genetics and biology. So when a pest attacks, the crop can kill the pest. At the moment, as an organic farmer — my father is one — you basically plant your crop and you pray, because if the pests come, you either squeeze them with your fingers or there is nothing you can do. Insisting that when there is a food supply crisis, we should all go organic is not just absurd, it is also morally reprehensible because we need more food, from lesser land.

But there are arguments. They will take you to certain specific farms and show you organic farming led to rising yields.

These are very, very high labour. So literally, if you have one person for one square metre, you can get a very high yield on a mixed farming system. But that is not how we feed billions of people in mega-cities, on mechanised farming, which need tractors over large areas.

You have used really rude descriptions for organic food.

The problem is with the conceptual level of organic. It is based on, what I call, naturalistic fallacy — so everything natural is good and everything artificial is bad... In fact, there was a disease outbreak of E.coli in organic bean sprouts in Germany in 2011, which killed 50 people. Now imagine if a GMO crop had killed 50 people. The media would have gone crazy. This almost made no headlines.

Much of the GM opposition is actually coming from Europe. I suspect a lot of the soyabean soil we import from the US is GM, but nobody tells us.

Yes it is Europe more than the US. But if you look at the funding source of many of the activist groups, they claim to be representing the farmers or Indian perspectives or African perspectives. All their money comes from Switzerland, from the UK, and from Germany. And so I question, whose ideological perspectives are being represented by these activists who say that they are supporting nationalist agendas but are actually supporting organic agendas or traditionalist agendas based on romantic misconceptions held in Europe, rather than the countries themselves.

And why is Europe so romantic?

Because we have a post-colonial guilt syndrome. So we are just protecting the 'traditional', protecting 'traditional values' and so on. That way we will shovel money about. As the former colonisers of this country, that makes us feel less guilty.

And you say again that there is no scientific evidence that GM technology causes harm.

Not even so much as a headache or stomach ache. There has never been a substantiated case of any impact on human health.

And the other bugbear of activists, nuclear energy? I notice you are taking on many demons at the same time.

Nuclear power is the safest form of power generation developed. I say this and people look at me like 'you are crazy'. But that is the reality... We cannot solve climate change without nuclear energy.

But when such a pro-science country like Germany bans nuclear energy, how do you persuade us Indians?

Germany has a strange position on this. I think it goes back to the war. They somehow identify nuclear with Adolf Hitler... But that does not apply to the rest of the world. India now has the choice between large-scale use of coal and large-scale use of nuclear. If it goes for coal, then the Maldives will sink and the rest of the climate is going to be pretty screwed worldwide.

One can agree with you or disagree with you, but the essence of science is questioning an argument. The essence of ideology is the opposite.

I would never say all GM crops will always be safe. If you can show conclusively that a certain crop poses health dangers, then absolutely we should not use it... It does not make sense to ban an entire technology on the basis of some purported risk and some unspecified data in the future.

Transcribed by Aslesha